LOCUS OL702894 19058 bp cRNA linear VRL 12-DEC-2021 DEFINITION Marburg marburgvirus isolate MARV001, complete genome. ACCESSION OL702894 VERSION OL702894.1 KEYWORDS . SOURCE Marburg marburgvirus ORGANISM Marburg marburgvirus Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Filoviridae; Marburgvirus. REFERENCE 1 (bases 1 to 19058) AUTHORS Faye,M., Diagne,M.M., Wiley,M.R., Magassouba,N., Faye,O. and Sall,A. TITLE First detection of a case of fatal Marburg virus disease in Guinea JOURNAL Unpublished REFERENCE 2 (bases 1 to 19058) AUTHORS Faye,M., Diagne,M.M., Wiley,M.R., Magassouba,N., Faye,O. and Sall,A. TITLE Direct Submission JOURNAL Submitted (03-DEC-2021) Virology Department, Institut Pasteur de Dakar, 36, Avenue Pasteur, Dakar, Senegal 220, Senegal COMMENT ##Assembly-Data-START## Assembly Method :: Prinseq-lite v. v0.20.4 Assembly Name :: Marburg virus Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..19058 /organism="Marburg marburgvirus" /mol_type="viral cRNA" /isolate="MARV001" /isolation_source="whole blood" /host="Homo sapiens" /db_xref="taxon:11269" /country="Guinea" /collection_date="09-Aug-2021" /note="subgroup: clade 'Angola 2005'" CDS 63..2150 /codon_start=1 /product="nucleoprotein" /protein_id="UFZ14317.1" /translation="MDLHSLLELGTKPTAPHVRNKKVILFDTNHQVSICNQIIDAINS GIDLGDLLEGGLLTLCVEHYYNSDKDKFNTSPIARYLRDAGYEFDVIKNADATRFLDV IPNEPHYSPLILALKTLESTESQRGRIGLFLSFCSLFLPKLVVGDRASIEKALRQVTV HQEQGIVTYPNHWLTTGHMKVIFGILRSSFILKFVLIHQGVNLVTGHDAYDSIISNSV GQTRFSGLLIVKTVLEFILQKTDSGVTLHPLVRTSKVKNEVTSFKQALSNLARHGEYA PFARVLNLSGINNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAAHDAEV KLQRRHERQEIQAIAEDDEERKILEQFHLQKTEITHSQTLAVLSQKREKLARLAAEIE NNIVEDQGFKQSQNRVSQSFLNDPTPVEVTVQARPINRPTALPPPVDGKIEHESTEDS SSSSSFVDLNDPFALLNEDEDTLDDSVMIPSTTSREFQGISEPPRQSQDLDNSQGKQE DESTNLIKKPFLRYQELPPVQEDDESEYTTDSQESIDQPGSDNEQGVDLPPPPLYAQE KRQDPIQHPAVSSQDPFGSIGDVNGDILEPIRSPSSPSAPQEDTRAREVYELSPDFTN YEDDQQNWPQRVVTKKGRTFLYPNDLLQTNPPESLMTALVEEYQNPVSAKELQADWPD MSFDERRHVAMNL" CDS 2904..3893 /codon_start=1 /product="VP35" /protein_id="UFZ14318.1" /translation="MWDSSYMQQVSEGLMTGKVPIDQVFGTNPLEKLYKRRKPKGTVG LQCSPCLMSKATSTDDIIWDQLIVRKTLADLLIPINRQISDIQSTLSEVTTRVHEIER QLHEITPVLKMGRTLEAISKGMSEMLAKYDHLVISTGRTTAPAAAFDAYLNEHGVPPP QPAIFKDLGVAQQACSKGTTVKNATTDAADKMSKVLELSEETFSKPNLSAKDLALLLF THLPGNNTPFHILAQVLSKIAYKSGKSGAFLDAFHQILSEGENAQAALTRLSRTFDAF LGVVPPVIRVKNFQTVPRPCQKSLRAVPPNPTIDKGWVCVYSSEQGETRALKI" CDS 4527..5438 /codon_start=1 /product="VP40" /protein_id="UFZ14319.1" /translation="MASSSNYNTYMQYLNPPPYADHGANQLIPADQLSNQQGITPNYM GDLNLDDQFKGDVCHAFTLEAIIDISAYNERTVKGVPAWLPLGIMSNFEYPLAHTVAA LLTGSYTITQFTHNGQKFVRVNRLGTGIPAHPLRMLREGNQAFIQNMVIPRNFSTNQF TYNLTNLVLSVQKLPDDAWRPSKDKLIGNTMHPAVSIHPNLPPIVLPTVKKQAYRQHK NPNNGPLLAISGILHQLRVEKVPEKTSLFRISLPADMFSVKEGMMKKRGENSPVVYFQ APENFPLNGFNNRQVVLAYANPTLSAV" CDS 5900..7945 /codon_start=1 /product="glycoprotein" /protein_id="UFZ14320.1" /translation="MKTTCLLISIILIQGVKTLPILEIASNIQPQNVDSVCSGTLQKT EDVHLMGFTLSGQKVADSPLEASKRWAFRTGVPPKNVEYTEGEEAKTCYNISVTDPSG KSLLLDPPTNIRDYPKCKTIHHIQGQNPHAQGIALHLWGAFFLYDRIASTTMYRGKVF TEGNIAAMIVNKTVHKMIFSRQGQGYRHMNLTSTNKYWTSSNGTQTNDTGCFGILQEY NSTKNQTCAPPKKPSPLPTAHPEVKLTSTSTDATELNTTDTNSDDEDLTTSGSGSGEQ EPYTTSDAATKQGLSSTMPPTPSPQPSTPQQGGNNTNHSQGVVTEPGKTNTTAQPSMP PHNTTTISTNNTSKHNLSAPSVPIQNATDYNTQSTATENEQTSAPSKTTLLPTENPTT AKSTNSTKSPTTTVPNTTNKYFTSPSPTPNSTAQHLVYFRRKRNILWREGDTFLFLDG LINAPIDFDPVPSIKTIFDESSSSGASAEEDQHASSNISLTLSYFPKINENTAYSGEN ENDCDAELRIWSVQEDDLAAGLSWIPFFGPGIEGLYTAGLIKNQNNLVCRLRRLANQT AKSLELLLRVTTEERTFSLINRHAIDFLLTRWGGTCKVLGPDCCIGIEDLSRNISEQI DQIKKDEQKEGTGWGLGGKWWTSDWGVLTNLGILLLLSIAVLIALSCICRIFTKYIG" CDS 8828..9673 /codon_start=1 /product="VP30" /protein_id="UFZ14321.1" /translation="MQQPRGRSRTRNHQATPSIYHETQLPSKPHYTNHHPRARSMSST RSSAESSPTNHIPRARPPSTFNLSKPPPPPKDMCRNMKIGLPCTDPTCNRDHDLDNLT NRELLLLMARKMLPNTDKTFRSPQDCGSPSLSKGLSKDKQEQTKDVLTLENLGHILSY LHRSEIGKLDETSLRAALSLTCAGIRKTNRSLINTMTELHINHENLPQDQNGVIKQTY TGIHLDKGGQFEAALWQGWDKRSISLFVQAALYVMNNIPCESSISVQASYDHFILPQS QGKGQ" CDS 10166..10927 /codon_start=1 /product="VP24" /protein_id="UFZ14322.1" /translation="MAELSTRYNLPVNVPEKSINLDLNSTARWIKEPSVGGWTVKWGN FVFHIPNTGMTLLHHLKSNFVVPEWQQTRNLFSHLFKNPKSTIIEPFLALRILLGVAL KDQELQQSLIPGFRSIVHMLSEWLLLEVTSAIHISPNLLGIYLTSDMFKILMAGVKNF FNKMFTLHVVNDHGKPSSIEIKLTGQQIIITRVNMGFLVEVRRIDIEPCCGETVLSES VVFGLVAEAVLREHSQMEKGQPLNLTQYMNSKIAI" CDS 11440..18435 /codon_start=1 /product="RNA-dependent RNA polymerase" /protein_id="UFZ14323.1" /translation="MQHPTQYPDARLSSPIILDQCDLLARSLGLYSHYSHNPKLRDCR IPHHIYRLRNSTALKTFLQNCSILTIPFHSIWDHILTSIQYDAINHVDDFKYLLPSEL VKYANWDNEFLKAYLNKILGLNRVFPTSARSQCEDFSPKENPYYWGMLLLVHLSQLAR RIKGQRGSLRSNWKFIGTDLELFGIADFVIFKVPVKTIIRNAVSLQASKPGLRVWYRD QNLTPYLCDDEFIVSVASYECFIMIKDVFIERYNTWEICARAWLEDSDGADYPPLDVL GELYNQGDQIIAMYLEDGFKLIKHLEPLCVSCIQTHGIFTPRKYWFQSQMIKSYYDEL CCLNLKLQISDHKAECAQNFIKTIIQAKLTPQQYCELFSLQKHWGHPVLYNDVALDKV KKHAQSTKILKPKVMFETFCVFKFIVAKNHYHSQGSWYKTTHDLHLTPYLRQHIVSNS FPSQAEIYQHLWEWYFVEHEPLFSTKIISDLSIFIKDRATAVNQECWDSVFDRSVLGY NPPVRFQSKRVPEQFLGQADFSLNQILDFAEKLEYLAPSYRNFSFSLKEKELNIGRTF GKLPYRVRNVQTLAEALLADGLAKAFPSNMMVVTEREQKEALLHQASWHHNSASIGEN AIVRGASFVTDLEKYNLAFRYEFTRHFIDYCNRCYGVKNLFDWMHFLIPLCYMHVSDF YSPPHCVTEDNRNNPPDCANAYHYHLGGIEGLQQKLWTCISCAQITLVELKTKLKLKS SVMGDNQCITTLSLFPVDAPNDYQENEAELNAARVAVELAITTGYSGIFLKPEETFVH SGFIYFGKKQYLNGVQLPQSLKTMARCGPLSDSIFDDLQGSLASIGTSFERGTSETRH IFPSRWIASFHSMLAINLLNQNHLGFPLGFNIDISCFKKPLTFSEKLIALITPQVLGG LSFLNPEKLFYRNISDPLTSGLFQLKNALEFLEKEELFYILIAKKPGLADASDFVMNP LGLNVPGSREIITFLRQTVRENITITSQNRIINSLFHIGSDLEDQRVCEWLLSSNPVM SRFAADIFSRTPSGKRLQVLGYLEGTRTLLASRTISLTTEGTMLMKLRELTRNRWKSW FSYIDALDDDLSESLEKFTCTVDVANFLRAYSWSDVLKGKRLIGATLPCLLEQFKVKW INLSEDLREQFNLSSDSESTINVLPYDCKELRLGGSNDTELNYVSCALDRKVVQKHPS VNRLAWTIGNRAPYIGSRTEDKIGYPPLRVNCPSAALKEAIEMVSRLLWVTQGTADRE KLLIPLLNSRVNLDYQTVLNFLPTHYSGNIVHRYNDQYGQHSFMANRMSNTSTRAIIS TNTLGKYAGGGQAALDSNIIFQNTINLGVAVLDIALSLAKLSSSSNVTFRLMLNKCCT RHVPSEYLFFDKPLDVDLNKYMDNELVYDNDPLCSGIKGRLGRVSRSTLSLSLNVSDI GSYDFPTIAAWTLGETIVGSIFSDESSQSTDPISSGCTKTFVTHFLVYPVESIFYAFG ANLIVESLSLNRIKSIKNLSDLTFLISSTIRNLSHRSLRILQSTFRHELVLTRLAHHI PLISLMLGGSAGEKSSSDAVRLFLTASYQNFINNFSCLIKKGQSSLPVWLYFPSEGQQ LKPILKILQRLSDLFSPDKVQKRKILADTCYPVDSFWVYPSKSTRTNHYYASLNYWRD KANKVKNTPFSHLINCSFLGLSSHTISVPSNQQMTNSKYIVHPKNIPEMNARTELINY GSTTLQGMDIKMPLSEQNLVEGCQLSKGIRCKDYQKIIKHDQRYGKKESSSRQMLPKD NMQTPAYIHGSSPSQTIIKSLGVHEDFDASKVILNSETNNPNLTDCTLNTKFLTTLTG TETLGTSPLQLSRYSSTSKERSLLSREQASYLYVDCSNIPSISLDPGFRNMSDQNQVQ MLINAYKRDLHACFDSNQFCRFTGVVSSMHYKLYDLLPPGELKKAICLAEGEGSGARL LLKWKETDYLFFNTLATDSQQEAEILSGRVIPRMLYNIDKLSVLLESRRLILNNLTIQ ITDITNPLWLDSVIQYLPEDSDILTMDAETTKDETREQLYKTIVNIWTRTSPNIPKIS IIKVFLLDYEGTLFLMRNAIQYYGQVQLKKPYSSNAKNSEWYLCCGKRRIQRLQIDFS DQVGIFLICKAMSRQRQAIPYWLKHIEKNYPASLHEFFLTLGFPSLESSFCHRYTIPF SEGKALFHKVQSYVRQGKQHLHSLMLDYENNSPLLDLRNHFICSLRGKITKYYNDILK LNLVIKAVEKGKNWSQLVETLPNMHSVCIVHVDHECFGCKKRLLLKLDFIRNTKIAEQ KLLNRVIGYILFFPFGLFKSGSLRA" ORIGIN 1 aaataaagaa gaatattaac attgacattg agacttgtca gtctgttaat attcttgaag 61 agatggattt acatagtttg ttagagttgg gtacaaaacc tactgctcct catgttcgta 121 ataagaaggt gatattattc gacacaaatc atcaggttag tatctgtaat cagataatag 181 atgcaataaa ctcagggatt gatcttggag accttttaga agggggtttg ctgacgttat 241 gtgttgaaca ctactataat tccgacaaag ataaattcaa cacaagtcct atcgcaagat 301 acttgcgtga tgcgggttat gaatttgatg tcatcaagaa tgcagatgca acccgctttc 361 tggatgtgat tcccaatgaa cctcattaca gccctttaat tctggccctt aagacattag 421 aaagcactga atctcagagg gggaggattg ggctcttttt gtcattttgc agtctttttc 481 tcccaaaact tgtcgtcgga gaccgggcca gtatcgaaaa ggccttaaga caagtgacag 541 tacatcaaga acaaggaatt gtcacatacc ctaatcattg gcttactaca ggtcacatga 601 aagtaatttt cgggatcttg aggtctagct ttattttaaa gtttgtgttg attcatcaag 661 gagtaaattt ggtgacaggt catgatgcat atgacagtat cattagcaat tcagtaggtc 721 aaactagatt ctcaggactt cttattgtga aaacagttct cgagttcatc ttgcaaaaaa 781 ctgattcagg ggtgacacta catcctttgg tgcggacctc caaagtgaaa aacgaagtta 841 ctagtttcaa gcaggcgttg agcaacttag cccgacacgg agagtacgca ccatttgcac 901 gggttttgaa tttatcaggg attaacaatc tcgaacatgg actctatcct cagctctcag 961 caattgcgct gggtgtagcg acagcacatg gcagtacatt ggctggtgtc aatgttggcg 1021 aacaatatca acagctacga gaggcagcac atgatgcaga agtaaaacta caaagacgac 1081 atgaacgtca ggaaattcaa gctattgccg aagatgacga ggaaaggaag atattagaac 1141 aattccacct tcagaaaact gaaatcacac acagtcagac actcgccgtc ctcagccaga 1201 aacgagaaaa attagcccgc cttgctgcag aaattgaaaa caatattgtg gaagatcagg 1261 gatttaaaca atcacagaat cgggtgtcac agtcgttttt gaatgaccct acgcctgtgg 1321 aagtgacagt tcaagccagg cccataaatc gaccaactgc tctgcctccc ccagtcgacg 1381 gcaaaatcga gcatgaatct acagaagata gctcttcttc aagcagcttt gttgacttga 1441 atgatccatt tgcactgctg aatgaggacg aagacactct tgatgatagt gtcatgatcc 1501 cgagcacaac atcgagagaa tttcaaggga tttctgaacc gccaagacaa tctcaggacc 1561 tcgataacag ccaaggaaag caggaagatg aatcaacaaa cctgattaag aaaccgtttt 1621 tacgatatca agaactgcct cctgtccaag aggatgatga atcagaatac acaactgact 1681 ctcaggaaag tattgaccag ccaggatccg acaatgaaca aggggttgat cttccacctc 1741 ctccgttgta tgctcaggaa aagagacagg acccaataca gcacccagca gtaagctctc 1801 aggatccctt tggcagtatt ggtgatgtaa atggtgatat cttagaaccc ataaggtcac 1861 cctcttcacc gtctgctcct caggaagaca caagggcaag agaagtctat gaattgtcac 1921 ctgatttcac aaattatgag gatgatcaac agaattggcc acaaagagtg gtgacaaaga 1981 agggtaggac tttcctttat cctaatgatc ttctgcagac aaatcctcca gaatcactta 2041 tgacagccct tgttgaggaa taccaaaatc ctgtctcagc caaggagctt caagcagatt 2101 ggcctgacat gtcatttgat gaaaggagac atgttgctat gaacttgtaa cccggatact 2161 acagcacaat tacccaccca tccacttcga tatgattcac tctcagatca cagcaatcaa 2221 ccctatttga atatccaaat cactatttag tatcctatta cttgtcacta ttgtgtgaga 2281 caacataagc tatcaaataa caatcacggg caagaactgg gcatacgatg gtgatttaag 2341 agtattgttc agtgctacaa attctttttt caattgctat aatgatacaa ctacaaacct 2401 ccgtacactt gccgcaatac tgtaattaac actgctgtat ctcttcctca agccatctga 2461 tttaactcaa taaacatgac ttgattcaga gaatatgctg aaaatgttat tgtttgaact 2521 tctaaaatgg cgcactatcc taccgtttta ctcagcttgg tatattgtaa catatcagcg 2581 aactctccac ttctcttctt gtatattctc tataaatcat ttacttgaca gaatgtcaag 2641 tctactggtc cggagtctcc ttactctaat gaatgtaata attaactgtt agcttagatg 2701 acaacagata tgaggttata taattactca tagtgtaaaa tgtaattctt acttttgttt 2761 cttctgtttt ccccctcctt tatgatatac taattaagaa aaactaaaaa tcgaagaata 2821 ttaaagattt tctttaatat tcagaaaagg ttttttattc tcttctttct ttttacaaat 2881 atattaaaat aatagttctc acaatgtggg actcatcata tatgcaacaa gtcagcgaag 2941 ggttgatgac tggaaaagtt cccatagatc aggtgtttgg taccaatccc ttagagaagc 3001 tatacaagag aaggaaacca aaaggcacag ttggactaca atgtagccct tgtctaatgt 3061 caaaggcaac aagtactgat gatattattt gggaccaact gatcgtgagg aaaacactag 3121 ctgatctact tataccgata aataggcaga tatcggatat tcaaagtact ctaagtgaag 3181 taacaacgag agtccatgaa attgagcggc aattacatga aatcacccca gttttgaaaa 3241 tgggaaggac actggaagca atctccaagg ggatgtcaga aatgttagct aaatatgacc 3301 accttgtaat ctcaactgga agaaccactg caccagctgc tgcctttgat gcttacttaa 3361 atgagcatgg tgtccctcct cctcaacccg cgatcttcaa agatcttggg gttgcccaac 3421 aagcttgcag caaggggacc acggttaaaa atgcaacaac agatgcagcc gacaagatgt 3481 cgaaggtcct cgaactcagt gaggaaacgt tctccaagcc aaacctctca gccaaggatt 3541 tagccctttt attgtttacc catctacctg gcaacaacac tccatttcac atccttgctc 3601 aggtcctttc aaaaattgct tacaagtcag gaaaatccgg agcatttttg gacgcatttc 3661 accaaatttt gagtgaagga gagaatgctc aggcggcatt aactcgacta agcagaacat 3721 ttgatgcctt cctcggagtg gttcctccag tgataagagt caaaaacttc caaacagtcc 3781 ctcgcccatg tcaaaaaagc cttcgggctg tccctccaaa tccaacaatc gacaaaggat 3841 gggtctgtgt ttattcatct gagcaaggtg agacacgggc tcttaaaatc taattctcat 3901 tgtccaaagt tgcaagggaa gttatcttct cgagttgata caaagacact aaacatttca 3961 aaaacatgta tgtgggtaaa acgtaactag accatcttaa ttggagtagt aatttatttc 4021 tgtcttagat gtgattttca cttcaaaaga gttaaatggt gatagattaa tctttgaaat 4081 tacccattta tatattatag agaaactaat gttactaaca aaaggggtct acctaacggg 4141 tatgatcgag tgatcagtct atcttataaa ccagacaatt gacttcttac tttttaagaa 4201 tcaactaaca gcatagaaac cacatttagc tttacgtaat ctttggctta gttggaatga 4261 acttttgttg taattcaaca catttagtca tagtatattg tagaattttt tataagttta 4321 gaatacctta aatcataccc acaaagaata ctgttttaat taagaaaaac tatgaagaac 4381 attaagaaga tctttctctc atagtgttct tttactggaa gaagtattcc aatcttaact 4441 tgttggatca gttgtcactt aagttgttat ttttaaaatt aattcacaca aagtagttta 4501 aatttgtatc tagaataaat tttaatatgg ccagttccag caattacaat acatacatgc 4561 aatatcttaa ccctcctcct tatgctgacc acggtgcaaa ccagttaatc ccggcggatc 4621 agctatcaaa tcagcagggt ataactccaa attatatggg cgatttaaac ctagatgacc 4681 agttcaaagg ggatgtctgc catgctttca ctttagaggc aataattgac atatctgcgt 4741 ataacgaacg aacagtcaaa ggcgttccgg catggctgcc tcttgggatt atgagcaatt 4801 tcgaatatcc tttagcccat acagtggctg cgttgctcac aggcagctat acaatcaccc 4861 aatttactca taatgggcaa aaattcgtcc gtgtcaatcg actcggtaca ggaatcccgg 4921 cacacccact caggatgttg cgtgaaggaa atcaagcttt tattcagaat atggtgatcc 4981 ccaggaattt ttccaccaat caattcacct acaatctcac taacttagta ttgagtgtgc 5041 aaaaacttcc tgatgatgcc tggcgtccat ccaaggacaa attaattgga aacaccatgc 5101 atcctgcagt ctccattcac ccgaatttgc cgcctattgt tctaccaaca gtcaagaagc 5161 aggcctatcg ccagcacaaa aatcccaaca atggtccact gctggccata tctggcatcc 5221 ttcatcaatt gagagtcgaa aaagtcccag aaaagacaag cttgtttagg atttcgcttc 5281 ctgccgacat gttctcagta aaagagggta tgatgaagaa aagaggagaa aattccccgg 5341 tagtttattt ccaagcacct gagaacttcc ctttgaatgg cttcaataac agacaagttg 5401 tactagcgta tgcgaatcca acactcagtg ccgtttaaaa tgatgctcaa ataaaacaga 5461 agtccatctg tataaggagt atggcttaaa tgggtatttg tcagattctt aagagattag 5521 tttgtattga tttaaataat gctttaacct tacattgctg ctttaaatgg ttgattaagc 5581 tgattagttt gtaatatata atctcttttg ggccatcaga tctgtaatgg gtttactaga 5641 ttatatacaa gaaacagtaa tattttataa ataattcttg ctcagttttg ctttgattta 5701 ataacataca tcattgtgcc tttcattgct aggtcaactt aactgataat gatattcctt 5761 ctgaaatagt aagaaaaact aatgaagaac attaattact gggtaaaagt gattaggttc 5821 tttaaatttg atcaaggtaa tattttgtca gtgaatatat tctcatatca tttgattaaa 5881 aacaggaaat tatcctaaaa tgaaaaccac atgtctcctt atcagtatta tcttaatcca 5941 aggggtaaaa actctcccta ttttagagat agccagtaac attcaacccc aaaatgtgga 6001 ttcagtatgc tccgggactc tccagaagac agaagacgtt catctgatgg gatttacact 6061 gagcgggcaa aaagttgctg attctccttt agaggcatcc aaacgatggg ccttcaggac 6121 aggcgtacct cccaagaatg ttgagtatac agaaggggag gaagctaaaa catgttacaa 6181 tataagtgta acggatccct ctggaaaatc cttgctgtta gatcctccta ccaacatccg 6241 tgactatcct aaatgcaaaa ctatccatca tattcaaggt caaaaccctc atgcacaggg 6301 gattgctctc catttgtggg gagcattttt cttgtatgat cgcatcgcct ccacaacaat 6361 gtatcgaggc aaagtcttca ctgaagggaa catagcagct atgattgtca ataagacagt 6421 gcacaaaatg attttctcga ggcaaggaca agggtaccgt cacatgaatc taacttctac 6481 taataaatat tggacaagta gcaacggaac gcaaacgaat gacactggat gcttcggtat 6541 tcttcaagaa tacaattcta caaagaacca aacatgtgct ccgcccaaaa aaccttcacc 6601 actgcccaca gcccatccgg aggtcaagct cactagcacc tcaactgatg ccaccgaact 6661 caataccaca gacacaaaca gtgatgatga ggacctcaca acatctggct cagggtctgg 6721 agaacaggaa ccttatacaa cttctgatgc ggccacgaag caagggcttt catcaacaat 6781 gccgcccact ccctcaccac aaccaagcac gccacagcaa ggaggaaaca acacaaatca 6841 ttcccaaggt gttgtgactg aacccggcaa aaccaacaca actgcacaac cgtccatgcc 6901 ccctcacaac actactacaa tctctactaa caacacctcc aagcacaacc tcagcgctcc 6961 ctctgtacca atacaaaatg ccactgatta caacacacag agcacggcca ctgaaaatga 7021 gcaaaccagt gccccctcaa aaacaaccct gcttcctaca gaaaatccta caacagcaaa 7081 gagcaccaac agtacaaaaa gccccactac aacagtacca aatacgacaa ataagtattt 7141 caccagtccc tcccccaccc ccaactcgac tgcgcaacat cttgtatatt ttagaaggaa 7201 acgaaatatc ctctggaggg aaggcgacac gttccttttt ctggatgggt taataaatgc 7261 tccgattgat tttgatccgg ttccaagtat aaagacaatc tttgatgaat cctctagttc 7321 tggtgcttca gctgaggaag atcaacatgc ctcctctaat atcagtttaa ctttatctta 7381 ctttcctaag ataaatgaaa acactgccta ctctggagag aatgaaaatg attgtgatgc 7441 agagttaaga atttggagtg ttcaggagga cgacctggca gcagggctca gttggatacc 7501 attttttggc cctggaatcg aaggacttta tactgctggt ttaattaaaa atcaaaataa 7561 tttggtttgc aggttgaggc gtctagctaa tcagactgcc aaatccttgg aactcttatt 7621 aagagtcaca accgaggaaa gaacattttc cttaatcaat agacatgcca ttgatttttt 7681 actcacaagg tggggaggaa catgcaaagt gcttggacct gattgttgca tcggaataga 7741 agacttgtcc agaaatattt cagaacaaat tgatcaaatc aaaaaagacg aacaaaaaga 7801 ggggactggt tggggtctgg gtggtaaatg gtggacatca gactggggtg ttcttactaa 7861 cttgggcatc ttgctactac tgtccatagc tgtcttaatt gctctgtcct gtatttgtcg 7921 tatttttact aaatatattg gataacatta agtgtgcaat gatgagaact ttaagataat 7981 tgctactgag cccttcttct gatccactga aatcaacttg ggagattctt gagaagctga 8041 caacttaatg tgaatcaaca gtttacgtat tatcgattat tatggtttga gattcaactg 8101 ttatcatcgt caagagtgac ctttcctact tgatgcatta atgttttaaa ctacctctta 8161 agcctttgtg gatggtctca atatgcgcgt aagggtgaat ttgaagagat ttcttgttgc 8221 atagtttttt gtattactta tttaggcttg aagacatagt taagactggc cgaaaatgct 8281 ctccagtcaa ctccatttcc tctcagggga gacgtgctgt ccaaagagtc ctaatccata 8341 accaaccatt gcaagaatta atttactttt tccgttatac ttatctacat taattctttg 8401 aatatccagc attattaacg acttgcctta cttcaatctt ttggatgcaa atcataagga 8461 aaaatgagcc actttccctc taccttaagc taaagaaatt tctcttatca gctcaaaata 8521 tgatccgtca ggtcacaggc cattcataat ctgtttgagc gttaatattg atcaaataac 8581 caaatgatgt tgcatttgta tagacgcaat tatcctttat taagaaaaag acaaatagaa 8641 cacaaatagt tgacaaaatt ttactttgat aaattttgcg aggaattata aaaatcttga 8701 aggataaatt atagtagagt agagtcgaag aacattaagt gttctttgtt agaattattc 8761 atccaagttg tttttgagta tattcgcttc aatacaactc ctctttatat ttgatttaag 8821 atttaaaatg caacaacctc gtggaagaag tcgaacccgt aaccaccaag ccacaccgtc 8881 tatatatcat gaaactcaat tgccctccaa accccattac acaaatcatc atccacgtgc 8941 aagatctatg agctcaaccc gtagtagtgc agaaagcagt cccaccaatc acattccccg 9001 tgctcgacca ccctcaacat tcaacttatc gaaaccccct cctcccccaa aggacatgtg 9061 caggaacatg aaaattggat tgccgtgcac tgatcccact tgtaataggg atcatgacct 9121 tgataatctg acaaatcgtg aacttttgct attgatggcc cgaaagatgc tccccaatac 9181 ggataagaca tttagaagtc cgcaggactg tgggtcaccg tctctttcta aagggctctc 9241 aaaagataaa caggagcaaa cgaaggatgt gttgaccttg gaaaatctag gacacatcct 9301 gagctacctc cacagatcag aaattgggaa gttggatgag acatcacttc gtgcagcatt 9361 aagtttgacg tgtgctggaa ttcgaaagac gaatagatcc ttgatcaaca ccatgacaga 9421 actacacatt aaccacgaaa atctcccgca agaccaaaat ggtgttatca agcagacata 9481 cacaggtatc caccttgata aaggaggtca attcgaagcc gccttatggc aaggttggga 9541 taagagatcg atatctctat ttgtacaagc agctttatat gtgatgaaca atatcccctg 9601 tgaatcatcg atcagtgtgc aagcctcata cgatcatttt attcttcctc aaagtcaagg 9661 caaaggacaa tgattattgt tcgaagattg acaatttgat cactttcggt tttcaatttc 9721 aatccttatt gcgagatttg gacacgatct tactaacttc aatgattgac cccaaattca 9781 agtttattaa aggctaagat gaaaataatc actagtttgt tgtaaattac tcgatcaaaa 9841 tgttcttaag ctatcttcaa cttaatgatg caactctgtt tcacctttct tttgatttca 9901 atgtcacagc tatatccaag tgtctaatta acaacttgta cctctaagga aaaccatgaa 9961 gaacattaag aaaaaggatg ttctgattct tcaactgaac ttgtatatcc tttattgata 10021 cccttgagag acaactgttg acgctagatc acggatcaag catatttcaa tcaaacatcc 10081 taaattttca atcgtacaca taataatcat tctggtagca ttgcttttca gtataggata 10141 ggtggtcgtg aaaagacttc caagcatggc agaattatca acacgttaca acttgcctgt 10201 gaatgttcca gaaaagagca taaatcttga tctcaattcc acagcacgat ggataaaaga 10261 acccagtgtt gggggctgga cagtgaagtg gggaaacttt gttttccaca taccaaatac 10321 tggaatgaca ttgttgcatc atttaaagtc taattttgtt gttccagagt ggcaacaaac 10381 aaggaatcta ttctcccatc tctttaaaaa tccgaaatca acaattatag aaccgttctt 10441 ggctctgagg atcttgcttg gagttgcttt gaaggaccaa gaattacagc aatcattgat 10501 tcctggattt aggtctattg ttcatatgct ttcggaatgg ttgctcctgg aggtcacgtc 10561 ggcaatccac attagtccta atctgttggg gatctatttg acttcagata tgtttaagat 10621 tctgatggca ggtgtgaaaa atttctttaa taagatgttc actctccatg tcgtaaatga 10681 ccacggaaaa cctagcagta ttgaaataaa gttaactggg caacagatca ttatcactcg 10741 tgttaatatg gggtttctag tggaagtcag gaggattgac atagaacctt gttgtggtga 10801 aacagtcctt tcagaatcag ttgtttttgg gctagtggct gaggcagttc taagagaaca 10861 tagtcaaatg gagaagggcc aacctctcaa tctgacgcaa tacatgaaca gcaaaattgc 10921 tatatgagtg gcttaaacta gcatgagtat ttccatttca accacataat aatgtcggag 10981 gcacagtaca ttatggttga ttatcctgta taataaagga tatacctacc ctgatttata 11041 tttactggta taaaatagta gcatcatctt atcaactagt tgtcatacaa taggctgttc 11101 ctataatctg atggtgaaag tataagctta tagagttacc atgagtcaca actgttgtat 11161 attgtccaaa atatatcttg tgcaagtggt gtgtgcttga atatgctgat gtaatacaca 11221 caaataatga ttgattaaga aaaatcaatg atggatatta aatgtccata aagcaggtgt 11281 cgtaaaatat tagggatttc aaatgctgcc agacttactg aattttacat aggattatat 11341 gattcttttc gatacacgtt acatctttag caaagtaatg aaaacagctt tatcatgtta 11401 gacgccaatt attcatctta agtgaatcct ttcttcaata tgcagcatcc aactcaatat 11461 cctgatgcaa ggttgtcctc tcctataatc ctagaccagt gtgacttatt agctagaagt 11521 ttagggttat atagtcatta ttcacataat ccaaaattgc gtgattgtag aattccacat 11581 cacatttacc gtttaaggaa ttcgacagcc ttaaagacat ttcttcagaa ctgttcaata 11641 ctcaccattc cttttcattc aatttgggat catattctaa cttccattca atatgatgca 11701 attaatcatg ttgatgattt taaataccta ttgccatctg agctagtcaa gtatgcaaat 11761 tgggacaacg agttcttaaa ggcatatctt aataagatct taggacttaa ccgtgttttt 11821 ccaacttctg caaggtcaca atgtgaggat ttttctccta aagaaaatcc ttattattgg 11881 gggatgttgt tactcgtaca tttgtcccaa cttgccagga ggataaaagg acaaagaggg 11941 tcattaagaa gtaactggaa gtttatagga acagatttgg agctgtttgg aatagcagat 12001 tttgttattt ttaaggttcc agtaaaaaca ataatccgaa atgctgtaag cttacaagct 12061 tcaaaaccag ggttaagagt atggtaccgt gaccaaaact tgacccccta tctatgcgac 12121 gatgagttta ttgtaagcgt cgctagttat gaatgtttta ttatgattaa agacgtcttc 12181 attgagaggt acaacacatg ggagatatgt gcccgcgctt ggctcgagga cagtgatgga 12241 gctgattatc ctcctcttga tgtgctaggt gagttataca accaaggaga tcaaattatt 12301 gccatgtacc tggaggacgg cttcaaattg attaaacact tagaaccttt atgtgttagc 12361 tgtatacaaa cacatggcat ttttacacca agaaaatact ggttccagtc acagatgatc 12421 aagtcatatt atgatgaact ctgttgtctc aatttgaagc ttcaaatttc agaccataaa 12481 gctgagtgtg cccaaaactt tattaaaact ataattcagg cgaaattgac ccctcaacaa 12541 tactgtgaat tattctctct acaaaagcat tggggtcatc ccgttctata caatgatgtt 12601 gcactagata aggtcaaaaa acatgcacaa tctacaaaaa tcttaaaacc taaagtcatg 12661 tttgaaacct tttgtgtttt caagttcata gtagcaaaga atcattatca ttctcaagga 12721 tcatggtata aaaccacaca tgatttgcat ttgactccat atcttagaca acatattgtg 12781 tcaaattcat ttccatccca agccgaaatt tatcaacatc tttgggagtg gtatttcgtg 12841 gagcatgaac ctcttttttc aactaaaata ataagtgatt taagtatttt cattaaagac 12901 agggccactg ctgtgaacca ggagtgttgg gatagtgtct ttgatagaag tgtattagga 12961 tataaccctc ctgttagatt tcagtcaaaa agagtgccag agcaattttt gggtcaagca 13021 gacttttcct tgaatcaaat attggatttt gctgaaaagt tggagtattt ggctccttct 13081 tataggaatt tttctttctc attaaaagaa aaagagttga atataggaag aacttttggg 13141 aaattaccgt atcgtgtcag aaatgtccaa acactcgcag aagccttgct ggcagatgga 13201 ttagcaaaag cattccctag taatatgatg gttgtcactg agagggaaca gaaagaagca 13261 ttactgcatc aggcttcttg gcaccataat tcagcaagca taggggaaaa cgctatagtg 13321 agaggtgcga gttttgtcac tgatcttgag aaatacaatc ttgccttccg atatgaattt 13381 acacggcatt tcatagacta ctgtaatcga tgttatggtg tgaagaattt attcgattgg 13441 atgcactttt taataccact atgttatatg catgtcagtg atttttatag cccaccacat 13501 tgtgtgacag aagataaccg aaataaccca cctgattgtg ccaatgctta ccattatcat 13561 ttaggaggta tagagggact tcaacagaaa ttgtggacat gtatatcatg tgcccaaatc 13621 acccttgtgg agttaaagac taaattaaaa ttaaagtcta gtgtcatggg tgataatcaa 13681 tgtataacaa ctctaagtct gtttccagtt gatgctccca atgattatca agagaacgaa 13741 gctgaattaa atgcagcgcg agttgctgtt gaattagcta ttactacggg ttatagtggt 13801 atatttttga agcctgaaga aacatttgtc cattcagggt tcatttattt tggcaaaaag 13861 caatatctta acggtgttca actgccacaa tcattgaaaa caatggcaag gtgtggaccc 13921 ttgtctgact ctatttttga tgatcttcaa ggctctctag ccagtattgg tacatccttt 13981 gagagaggaa caagtgagac gcggcacatt tttccaagtc gttggatagc ttcatttcat 14041 tcaatgttag caataaattt attaaatcag aatcaccttg gatttcccct agggttcaat 14101 attgatattt cttgcttcaa aaagcctctt actttctcgg aaaaattaat tgccctcata 14161 acgccccaag ttttaggagg gttatcattt ttgaatccag agaaattgtt ctaccggaac 14221 ataagtgatc ctctcacttc aggtctattc caactcaaga atgcattgga atttcttgaa 14281 aaggaagaat tattctatat attgattgct aaaaaacctg gtttagcaga cgcctcagat 14341 ttcgtcatga atcctttagg cttaaatgta ccaggatcaa gggaaataat aacgttcctt 14401 agacagacag ttcgtgaaaa tatcacaatc acatcgcaaa atagaataat aaattctctt 14461 ttccacatag gctctgattt agaggaccaa agggtgtgtg agtggctttt atcatcaaac 14521 cccgtaatga gccgatttgc tgctgacatc ttttcaagaa cacccagtgg aaaacggctt 14581 caagtcttag gctatctgga aggaacaaga acattgctag cttctcggac aatcagttta 14641 actacagaag ggacaatgtt gatgaaatta agggaattaa caagaaaccg atggaaaagc 14701 tggttctctt atattgatgc actggacgat gatttatctg agtctttaga aaaattcaca 14761 tgcacagttg atgtagctaa tttcttgagg gcatattcat ggtctgacgt tttaaaaggg 14821 aaaagactaa ttggtgctac attaccgtgt ttactagagc aatttaaggt aaagtggatt 14881 aatttatctg aggatttaag ggaacaattt aatctgtctt cagactcaga atcaactata 14941 aatgtgttgc catatgactg caaggaactg cgacttggag gaagcaatga cacagaattg 15001 aattatgtca gttgtgctct tgaccggaaa gttgtccaga aacatccctc tgttaatcgt 15061 cttgcttgga cgataggaaa tcgggcaccg tatataggct cacggacaga agataagatc 15121 ggttatcctc ccttaagagt aaactgccca tcagcagcac ttaaagaagc tattgagatg 15181 gtttctagat tgttatgggt gactcaaggc actgcagacc gagagaaatt gcttattcct 15241 cttctcaatt cgagagtaaa tctggactat cagacagtgc ttaacttttt acctacacac 15301 tactcaggca atatagttca tagatataat gatcaatatg gacaacattc ctttatggca 15361 aataggatga gtaatacttc cacacgtgca attatatcaa ctaacacact gggtaaatac 15421 gcagggggag gtcaagctgc tcttgatagt aatataatct ttcaaaatac tattaactta 15481 ggggttgcag ttttagatat tgcattatct cttgctaaac tgtcgtcatc atcaaatgtc 15541 acttttcgtt tgatgttaaa taaatgctgc acacggcatg taccgtccga atacctgttt 15601 tttgataaac ctttagatgt ggatctgaac aagtatatgg ataatgaact ggtttatgac 15661 aatgatcccc tttgcagtgg gattaaaggg agattaggca gagtgtctcg atcaacactc 15721 tcattgagtt tgaatgtcag cgacattggt tcttatgact ttccaactat tgctgcatgg 15781 acactaggag aaactatagt cggaagcatt ttttctgatg agtcttctca aagcacagat 15841 ccaataagtt caggttgcac aaaaactttc gtcacacatt ttcttgtgta tccagttgag 15901 agtatttttt atgcatttgg agctaactta atagtggaaa gtttaagtct aaataggatc 15961 aaatcaatca agaacctttc agatttaaca ttccttatat cgtccacaat caggaattta 16021 tcacatagat cacttcggat tcttcagtct actttccgac atgaattggt gctcacccga 16081 ttagcccatc acataccgtt gatttcttta atgttagggg gctctgcagg agagaaaagt 16141 tcatcagatg ccgtccggct atttcttaca gcaagttatc agaatttcat caacaatttc 16201 agttgtctaa taaaaaaggg ccaatcatca ctaccagttt ggctttactt tcctagcgaa 16261 gggcaacagt taaaacctat attgaaaatc ttacagaggt tatcagactt gttttcacct 16321 gacaaagttc aaaagcgtaa aattttagct gacacctgtt atccagttga tagcttttgg 16381 gtttatccaa gcaagtccac aaggaccaac cattattatg caagccttaa ttattggaga 16441 gataaagcta ataaggtcaa gaatactcct ttttcacatt tgataaattg ttcatttctt 16501 ggactttctt cacataccat ttcagtccct tctaatcaac aaatgaccaa ttcaaagtat 16561 attgttcatc caaaaaatat ccctgaaatg aatgcaagaa ccgaattaat aaattatgga 16621 tcaacaactt tacaggggat ggacatcaaa atgccactct cagagcaaaa tctagttgaa 16681 ggttgtcaac tatcaaaggg catcagatgc aaggactatc aaaaaataat aaaacatgac 16741 cagagatatg ggaagaagga gtcctcatcg cgacaaatgc tccccaaaga caacatgcaa 16801 actcctgcgt acatacatgg ctcctcccca tctcaaacca ttataaaatc actaggtgta 16861 catgaggact ttgatgcctc gaaggtaatc ttaaattctg aaacaaataa ccctaacctt 16921 acagattgta ccctgaatac aaagttcttg acaactctca ccgggacaga aactttaggt 16981 acaagtccat tacaactctc tagatattca tcaacttcca aggaacggtc tctactatct 17041 agagaacaag cttcatattt gtatgttgat tgcagcaata ttccttctat ctctctagac 17101 ccgggttttc ggaatatgtc tgatcagaat caagttcaaa tgttaatcaa tgcctataaa 17161 cgtgatttac atgcttgttt cgatagcaat caattctgtc gttttacagg ggtagtctca 17221 tcaatgcatt ataagcttta tgatcttttg cctccaggtg aattgaaaaa ggcaatttgc 17281 ttggctgaag gggaaggaag tggtgctcgg ttacttttga agtggaagga aactgattat 17341 ttattcttca acactctggc tacagattca cagcaagaag cagagatctt gagtggccgg 17401 gtaataccga gaatgttgta taatatagac aaattaagtg ttttgcttga atcaagaaga 17461 ctaatattga acaatctaac tatccagatt acagatatta caaatccatt gtggctagat 17521 tctgtaatac aatatttacc tgaagatagt gatattctta caatggatgc agagaccact 17581 aaggatgaaa caagggaaca gctttataag actattgtga atatttggac acgtacttcc 17641 cctaatatcc caaaaattag tatcatcaag gtgtttttat tagactatga agggacttta 17701 ttcttaatga ggaatgccat tcagtattat gggcaagttc aactcaagaa accatatagc 17761 tcaaatgcaa aaaactcaga atggtacttg tgttgcggta aacgaaggat tcaacgactc 17821 caaattgatt tctcagacca ggtgggaatt tttctgattt gtaaagcaat gtcgcgccag 17881 agacaagcaa ttccttattg gttaaaacat atagaaaaga attatcctgc ttcattacat 17941 gaatttttcc taactttggg ttttccttct ttagagtcat ctttctgcca ccgttatact 18001 attccattca gtgaaggaaa ggctcttttc cataaagtcc agtcttatgt tcgtcaaggc 18061 aaacaacatt tgcattctct tatgttggat tacgaaaaca attcaccttt actagacttg 18121 agaaatcact ttatttgctc attaagggga aagataacta aatattacaa tgatatacta 18181 aagttaaatc tagtcatcaa agccgtggaa aaaggtaaaa actggtcaca acttgttgag 18241 acccttccca atatgcattc agtatgcata gtacacgtag accatgagtg ttttggatgc 18301 aaaaaacggt tattacttaa attggatttt attagaaata caaagatcgc agagcaaaaa 18361 ttgcttaata gagtaatcgg gtatatcctg ttctttccgt tcggtctgtt taaatctgga 18421 tcattaaggg cataacttta acagagggaa cctcatttaa ttcacaaaaa taacctattt 18481 aaaagtgggg gttaaatttt ctagggtgtt gtatgagaaa tcataaaata aacaagaaaa 18541 agaaaaagct attagacagc ttactttata gaagataatc ttataacacc ttaggcctta 18601 cacaggttag aaaattacgc acacagatta acttgtggtt gaacggtcag ttacaacaat 18661 ggtgactttt tcatgttggt tattcaaaca ttattgatca taattagcac cagcattggc 18721 acactgtgtg aaaccctgag cctcatccct aacatgaggc aagagaccaa gggaacactg 18781 aaacatacta gttggactga gctacaacat gccatatatc ataaatataa aagaactgtc 18841 tgctgtaatc tataagcctc tcttttatat acattggaga aagaacgagg ttatcattgt 18901 gatcaaaaaa cctacgttac attttctcag atgacaagtg ataaaatttc gtagttaaat 18961 ttctagaatg tcaatgtgaa tgtaaattaa gaaaaaccaa tatataaaat taaaaaagta 19021 aaaagctttg atacaagtaa cacaaaacat tcttcatc //